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【结 构 式】 
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【药物名称】Methyl aminolevulinate, Aminolevulinic acid methyl ester, ALA Me ester, P-1202, Metvix PDT, Metvix 【化学名称】5-Amino-4-oxopentanoic acid methyl ester 【CA登记号】33320-16-0, 79416-27-6 (hydrochloride) 【 分 子 式 】C6H11NO3 【 分 子 量 】145.15947 |
【开发单位】Norsk Hydro (Supplier), PhotoCure (Originator), Penn (Not Determined), Galderma (Marketer) 【药理作用】Actinic Keratoses, Agents for, Basal Cell Carcinoma Therapy, DERMATOLOGIC DRUGS, Oncolytic Drugs, Photodynamic Therapy, Squamous Cell Carcinoma Therapy |
合成路线1
The desired product can be easily obtained by formation of the methyl ester of the commercially available 5-amino-levulinic acid hydrochloride (I) by heating in MeOH in the presence of HCl.
| 【1】 Moan, J.; Steen, H.; Gierskcky, K.E.; Warloe, T.; Bjorseth, A.; Peng, Q. (PhotoCure ASA); Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy. US 6034267; WO 9628412 . |
Extended Information