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【结 构 式】

【药物名称】EGIS-9377

【化学名称】2-(Methylsulfanyl)-N-[2-(4-morpholinyl)ethyl]-8,9-dihydro-7H-thiopyrano[3,2-d][1,2,4]triazolo[1,5-a]pyrimidin-5-amine dihydrochloride

【CA登记号】144430-52-4 (free base)

【 分 子 式 】C15H24Cl2N6OS2

【 分 子 量 】439.43213

【开发单位】Egis (Originator)

【药理作用】CARDIOVASCULAR DRUGS, Heart Failure Therapy, Positive Inotropic Agents, Calcium Sensitizers

合成路线1

The title compound was prepared by condensation of 5-chloro-2-(methylsulfanyl)-8,9-dihydro-7H-thiopyrano[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidine (I) with N-(2-aminoethyl)morpholine (II) in the presence of Et3N in refluxing isopropanol.

1 Reiter, J.; Berecz, G.; Zsila, G.; Petocz, L.; Gigler, G.; Fekete, M.; Szecsey, M.; Szirt, E.; Rohacs, L.; Gorgenyl, F.; Csorgo, M. (Egis Pharmaceuticals Ltd.); 1,2,4-Triazolo[1,5-a]pyrimidine derivs.. EP 0500136; GB 2254611; JP 1993148267 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 37349 5-chloro-8,9-dihydro-7H-thiopyrano[3,2-d][1,2,4]triazolo[1,5-a]pyrimidin-2-yl methyl sulfide; 5-chloro-2-(methylsulfanyl)-8,9-dihydro-7H-thiopyrano[3,2-d][1,2,4]triazolo[1,5-a]pyrimidine C9H9ClN4S2 详情 详情
(II) 12880 4-(2-Aminoethyl)morpholine; 2-(4-Morpholinyl)ethylamine; 2-(4-Morpholinyl)-1-ethanamine; N-(2-Aminoethyl)morpholine; N-Morpholine ethanamide 2038-03-1 C6H14N2O 详情 详情
Extended Information