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【结 构 式】 
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【药物名称】DF-2 【化学名称】3-[(3S,9S,9aS)-9-Hydroxy-4,4-dimethyl-2-oxoperhydroquinolizin-3-yl]quinazolin-4(3H)-one 【CA登记号】 【 分 子 式 】C19H23N3O3 【 分 子 量 】341.41346 |
【开发单位】Okayama University (Originator), Tohoku College of Pharmacy (Originator), Tohoku University (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antimalarials, Treatment of Protozoal Diseases |
合成路线1
The isomerization of febrifugine (I) by means of HCl in methanol gives isofebrifugine (II), which is then cyclized with acetone over SiO2.
| 【1】 Takaya, Y.; Takeshita, M.; Kim, H.-S.; Wataya, Y.; Uwai, K.; Oshima, Y.; Tasaka, H.; Chiba, T.; Miura, M.; Tanitsu, M.-a.; New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite. J Med Chem 1999, 42, 16, 3163. |
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