【结 构 式】 |
【药物名称】DAA-1106 【化学名称】N-(2,5-Dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide 【CA登记号】220551-92-8 【 分 子 式 】C23H22FNO4 【 分 子 量 】395.43449 |
【开发单位】Nihon Nohyaku (Originator), Taisho (Originator) 【药理作用】Anxiolytics, PSYCHOPHARMACOLOGIC DRUGS, GABA(A) BZ Site Receptor Agonists |
合成路线1
5-Fluoro-2-phenoxyaniline (I) was acylated with acetyl chloride and triethylamine to afford acetamide (II). Alkylation of the amide N by 2,5-dimethoxybenzyl chloride (III) in the presence of NaH provided the target tertiary amide.
【1】 Yamamoto, Y.; Yoshida, M.; Nakamura, T.; Tomisawa, K.; Harada, K.; Nagamine, M.; Nakazato, A.; Chaki, S.; Okubo, T. (Nihon Nohyaku Co., Ltd.; Taisho Pharmaceutical Co., Ltd.); Aryloxyaniline derivs.. EP 1004573; JP 1999171844; US 2002147191; US 6333358; US 6476056; WO 9906353 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 56384 | 5-fluoro-2-phenoxyphenylamine; 5-fluoro-2-phenoxyaniline | C12H10FNO | 详情 | 详情 | |
(II) | 56385 | N-(5-fluoro-2-phenoxyphenyl)acetamide | C14H12FNO2 | 详情 | 详情 | |
(III) | 21994 | 2-(chloromethyl)-4-methoxyphenyl methyl ether; 2-(chloromethyl)-1,4-dimethoxybenzene | 3840-27-5 | C9H11ClO2 | 详情 | 详情 |
Extended Information