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【结 构 式】 
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【药物名称】BM-212 【化学名称】1-[1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-ylmethyl]-4-methylpiperazine 【CA登记号】146204-42-4 【 分 子 式 】C23H25Cl2N3 【 分 子 量 】414.3818 |
【开发单位】Università degli Studi "La Sapienza" (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Antimycobacterial Agents |
合成路线1
Friedel-Crafts acylation of chlorobenzene (I) with levulinic acid chloride (II) afforded diketone (III), which was converted to pyrrole (V) by condensation with 4-chloroaniline (IV) in the presence of a catalytic amount of HBr. Mannich reaction of (V) with formaldehyde and N-methylpiperazine (VI) then provided the target aminomethyl pyrrole.
| 【1】 Retico, A.; Cerreto, F.; Scalzo, M.; Villa, A.; Studies on anti-Candida agents with a pyrrole moiety. Synthesis and microbiological activity of some 3-aminomethyl-1,5-diaryl-2-methyl-pyrrole derivatives. Eur J Med Chem 1992, 27, 7, 701. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10190 | 1-Chlorobenzene | 108-90-7 | C6H5Cl | 详情 | 详情 |
| (II) | 28526 | 4-oxopentanoyl chloride | C5H7ClO2 | 详情 | 详情 | |
| (III) | 28527 | 1-(4-chlorophenyl)-1,4-pentanedione | C11H11ClO2 | 详情 | 详情 | |
| (IV) | 12034 | 4-Chlorophenylamine; 4-Chloroaniline; p-Chloroaniline | 106-47-8 | C6H6ClN | 详情 | 详情 |
| (V) | 28528 | 1,2-bis(4-chlorophenyl)-5-methyl-1H-pyrrole | C17H13Cl2N | 详情 | 详情 | |
| (VI) | 10061 | 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine | 109-01-3 | C5H12N2 | 详情 | 详情 |
Extended Information