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【结 构 式】 
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【药物名称】PH-104 【化学名称】1-(4-Cyclohexylphenyl)-3-(3,5-dimethoxyphenyl)-2(E)-propen-1-one 【CA登记号】219298-43-8 【 分 子 式 】C23H26O3 【 分 子 量 】350.46187 |
【开发单位】Danish University of Pharmaceutical Sci. (Originator), Statens Serum Institute (Originator) 【药理作用】Antibacterial Drugs, ANTIINFECTIVE THERAPY, Antileishmanials, Treatment of Protozoal Diseases |
合成路线1
Title compound was prepared by Claisen Schmidt condensation of 4'-cyclohexylacetophenone (I) with 3,5-dimethoxybenzaldehyde (II) in EtOH using NaOH as the catalyst.
| 【1】 Nielsen, S.F.; Christensen, S.B.; Gruciani, G.; Kharazmi, A.; Liljefors, T.; Antileishmanial chalcones: Statistical design, synthesis, and three-dimensional quantitative structure-activity relationship analysis. J Med Chem 1998, 41, 24, 4819. |
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