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【结 构 式】 
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【药物名称】 【化学名称】4-Nitro-N-[1,2,3-tris(acetyloxy)-5,6,7,9-tetrahydro-10- (methylsulfanyl)-9-oxobenzo[a]heptalen-7(S)-yl]- benzamide 【CA登记号】 【 分 子 式 】C30H26N2O10S 【 分 子 量 】606.61312 |
【开发单位】Natl. Cancer Inst., Frederick, MD (US); Univ. North Carolina, Chapel Hill, NC (US) 【药理作用】ONCOLYTIC DRUGS，DNA-INTERCALATING DRUGS |
合成路线1
Thiocolchicine (II) was prepared from colchicine (I) by treatment with sodium methylthiolate. Then, hydrolysis of acetamide group with methanolic HCl afforded deacetyl thiocolchicine (III). Subsequent acylation with p-nitrobenzoyl chloride (IV) in the presence of pyridine provided amide (V), which was demethylated with excess BBr3 to give the corresponding triphenol (VI). Finally, esterification with acetyl chloride in the presence of pyridine and 4-(dimethylamino)pyridine furnished the target triacetate.
| 【1】 Guan, J.; et al.; Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors. J Med Chem 1998, 41, 11, 1956. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18479 | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide | 64-86-8 | C22H25NO6 | 详情 | 详情 |
| (II) | 18480 | N-[(7S)-1,2,3-trimethoxy-10-(methylsulfanyl)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide | C22H25NO5S | 详情 | 详情 | |
| (III) | 18481 | (7S)-7-amino-1,2,3-trimethoxy-10-(methylsulfanyl)-6,7-dihydrobenzo[a]heptalen-9(5H)-one | C20H23NO4S | 详情 | 详情 | |
| (IV) | 18941 | p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride | 122-04-3 | C7H4ClNO3 | 详情 | 详情 |
| (V) | 18483 | 4-nitro-N-[(7S)-1,2,3-trimethoxy-10-(methylsulfanyl)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]benzamide | C27H26N2O7S | 详情 | 详情 | |
| (VI) | 18484 | 4-nitro-N-[(7S)-1,2,3-trihydroxy-10-(methylsulfanyl)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]benzamide | C24H20N2O7S | 详情 | 详情 |