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【结 构 式】 
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【药物名称】 【化学名称】N,N',N'',N'''-(1,4,8,11-Tetraazacyclotetradecan-1,4,8,11-tetrayl)tetrakis(pentane-1,5-diyl)tetrakis(N-benzylcarbamic acid tert-butyl ester) 【CA登记号】192518-27-7 【 分 子 式 】C78H124N8O8 【 分 子 量 】1301.90678 |
【开发单位】INSERM (Originator) 【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY |
合成路线1
The title compound was obtained by alkylation of tetraazacyclo tetradecane (I) with an excess of tosylate (II) in the presence of K2CO3 in refluxing acetonitrile.
| 【1】 Trabaud, C.; Dessolin, J.; Camplo, M.; Hantz, O.; Zoulim, F.; Borel, C.; Meyer, M.; Pepe, G.; Chermann, J.-C.; Kraus, J.-L.; Design, synthesis and structure relationships of new N,N',N'',N'''-tetrakis (omega-amino alkyl) tetraazamacrocycles. Antivir Chem Chemother 1998, 9, 1, 73-84. |
| 【2】 Chermann, J.C.; Dessolin, J.; Bouygues, M.; Trabaud, C.; Kraus, J.L.; Vieghe, P.; Camplo, M.; Modelisation, synthesis and anti-HIV activities of N,N,N',N'',N'''-pentakistetraazamacrocycles salts derivatives. Bioorg Med Chem Lett 1997, 7, 10, 1353. |
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