Saussureamine C, -Drug Synthesis Database

【结构式】

【药物名称】Saussureamine C

【化学名称】(-)-N2-[(3R,3aS,9bS)-6,9-Bismethylene-2-oxoperhydroazulene[4,5-b]furan-3-ylmethyl]-L-asparagine

【CA登记号】148245-83-4

【分子式】C₁₉H₂₆N₂O₅

【分子量】362.42947

【开发单位】Kuraray (Originator)

【药理作用】Antiulcer Drugs, GASTROINTESTINAL DRUGS

合成路线1

By condensation of dehydrocostus lactone (I) (isolated from the dried roots of Chinese plant Saussurea lappa) with L-asparagine (II) by means of Et3N in refluxing ethanol.

参考文献中间体

【1】 Matsuda, H.; et al.; Absolute stereostructures and syntheses of saussureamines A, B, C, D and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots of Saussurea lappa. Tetrahedron 2000, 56, 39, 7763.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42285	(3aS,6aR,9aR,9bR)-3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one		C₁₅H₁₈O₂	详情	详情
(II)	25972	S-(+)-Asparagine; S-(+)-2-Aminosuccinamic acid; L-Asparagine	70-47-3	C₄H₈N₂O₃	详情	详情

Extended Information