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【结 构 式】 
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【药物名称】Lubeluzole, JK-8792, R-87926, Prosynap 【化学名称】(+)-(S)-1-[4-[N-(Benzothiazol-2-yl)-N-methylamino]piperidin-1-yl]-3-(3,4-difluorophenoxy)-2-propanol 【CA登记号】144665-07-6 【 分 子 式 】C22H25F2N3O2S 【 分 子 量 】433.52425 |
【开发单位】Janssen (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Glutamate Release Inhibitors |
合成路线1
The reaction of 3,4-difluorophenol (I) with (S)-oxiranylmethyl p-toluenesulfonate ester (II) by means of NaH in DMF gives (S)-(3,4-difluorophenoxymethyl)oxirane (III), which is then condensed with N-(2-benzothiazolyl)-N-methyl-N-(4-piperidyl)amine (IV) by means of Na2CO3 in refluxing isopropanol or butanol/water.
| 【1】 Graul, A.; Castañer, J.; Lubeluzole. Drugs Fut 1997, 22, 6, 629. |
| 【2】 Stokbroekx, R.A.; Grauwels, G.A.J. (Janssen Pharmaceutica NV); 4-[(2-Benzothiazolyl)methylamino]-alpha-[(3,4-difluorophenoxy)methyl]-1-piperidineethanol. EP 0501552; EP 0573473; JP 1994505012; US 5434168; WO 9214731 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16739 | 3,4-difluorophenol | 2713-33-9 | C6H4F2O | 详情 | 详情 |
| (II) | 16740 | (2S)-(+)-Glycidyl tosylate; (2S)oxiranylmethyl 4-methylbenzenesulfonate | 70987-78-9 | C10H12O4S | 详情 | 详情 |
| (III) | 16741 | (2S)-2-[(3,4-difluorophenoxy)methyl]oxirane; 3,4-difluorophenyl (2S)oxiranylmethyl ether | C9H8F2O2 | 详情 | 详情 | |
| (IV) | 16742 | N-(1,3-benzothiazol-2-yl)-N-methyl-N-(4-piperidinyl)amine; N-methyl-N-(4-piperidinyl)-1,3-benzothiazol-2-amine | C13H17N3S | 详情 | 详情 |
合成路线2
A new synthesis of lubeluzole has been reported: The condensation of 3,4-difluorophenol (I) with racemic glycidol (II) by means of PPh3 and DEAD in THF gives 2-(3,4-difluorophenoxymethyl)oxirane (III), which is opened by means of Li2CuCl4 in THF yielding racemic 1-chloro-3-(3,4-difluorophenoxy)-2-propanol (IV). Racemic compound (IV) is kinetically resolved by transesterification with vinyl butyrate using Rhizomucor miehei lipase (RML) as catalyst, providing a mixture of (R)-1-chloro-3-(3,4-difluorophenoxy)-2-propanol (V) and the (S)-butyrate (VI). This mixture is easily separated by column chromatography. Finally, the (R)-alcohol (V) is condensed with N-methyl-N-(piperidin-4-yl)benzothiazol-2-amine (VII) by means of NaHCO3 in hot DMF. The key intermediate N-methyl-N-(piperidin-4-yl)benzothiazol-2-amine (VII) has been obtained as follows: Reductive amination of 4-oxopiperidine-1-carboxylic acid ethyl ester (VIII) with methylamine and borane/pyridine complex in methanol gives 4-(methylamino)piperidine-1-carboxylic acid ethyl ester (IX), which is condensed with isothiocyanatobenzene (X) in isopropyl ether to yield the thiourea (XI). Cyclization of compound (XI) by means of Br2 in refluxing CCl4 affords the benzothiazole derivative (V), which is finally decarboxylated by means of HBr in refluxing water, followed by treatment with NaOH.
| 【1】 Liu, H.L.; Helgehoff, B.; Berg, T.C.; Anthonsen, T.; Synthesis of the antistroke drug lubeluzole and its enantiomer. Lipase-catalyzed resolution of chiral building block. Chirality 2001, 13, 3, 135. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16739 | 3,4-difluorophenol | 2713-33-9 | C6H4F2O | 详情 | 详情 |
| (II) | 29648 | 2-oxiranylmethanol | 556-52-5 | C3H6O2 | 详情 | 详情 |
| (III) | 47537 | 2-[(3,4-difluorophenoxy)methyl]oxirane; 3,4-difluorophenyl 2-oxiranylmethyl ether | C9H8F2O2 | 详情 | 详情 | |
| (IV) | 47534 | 1-chloro-3-(3,4-difluorophenoxy)-2-propanol | C9H9ClF2O2 | 详情 | 详情 | |
| (V) | 47535 | (1S)-2-chloro-1-[(3,4-difluorophenoxy)methyl]ethyl butyrate | C13H15ClF2O3 | 详情 | 详情 | |
| (VI) | 47536 | (2R)-1-chloro-3-(3,4-difluorophenoxy)-2-propanol | C9H9ClF2O2 | 详情 | 详情 | |
| (VII) | 13486 | Ethyl 4-oxo-1-piperidinecarboxylate; N-Carbethoxy-4-piperidone | 29976-53-2 | C8H13NO3 | 详情 | 详情 |
| (VIII) | 22145 | ethyl 4-(methylamino)-1-piperidinecarboxylate | C9H18N2O2 | 详情 | 详情 | |
| (IX) | 22146 | 1-isothiocyanatobenzene; phenyl isothiocyanate | 103-72-0 | C7H5NS | 详情 | 详情 |
| (X) | 22147 | ethyl 4-[(anilinocarbothioyl)(methyl)amino]-1-piperidinecarboxylate | C16H23N3O2S | 详情 | 详情 | |
| (XI) | 22148 | ethyl 4-[1,3-benzothiazol-2-yl(methyl)amino]-1-piperidinecarboxylate | C16H21N3O2S | 详情 | 详情 | |
| (XII) | 16742 | N-(1,3-benzothiazol-2-yl)-N-methyl-N-(4-piperidinyl)amine; N-methyl-N-(4-piperidinyl)-1,3-benzothiazol-2-amine | C13H17N3S | 详情 | 详情 |