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【结 构 式】 
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【药物名称】OPB-9195 【化学名称】(±)-2-(Isopropylidenehydrazono)-5-[N-(phenyl)carbamoylmethyl]thiazolidin-4-one 【CA登记号】163107-50-4 【 分 子 式 】C14H16N4O2S 【 分 子 量 】304.37322 |
【开发单位】Otsuka (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Diabetic Nephropathy, Agents for, ENDOCRINE DRUGS, Hypertension, Treatment of, Treatment of Diabetic Complications, AGE Inhibitors (Maillard's Reaction Inhibitors) |
合成路线1
The title amide was prepared by coupling of the previously reported 5-carboxymethyl-2-isopropylidenehydrazonothiazolidin-4-one (I) with aniline (II) in the presence of EDC and HOBt.
| 【1】 Yasumura, K.; Miyajima, K.; Nagahama, T.; Ishikawa, S.; Tohyama, Y.; Sugiyama, K. (Otsuka Pharmaceutical Co., Ltd.); Thiazole or imidazole derivs. as Maillard reaction inhibitors. EP 0638075; JP 1995133264; JP 1998167965; WO 9419335 . |
Extended Information