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【结 构 式】

【药物名称】Dexloxiglumide, CR-2017

【化学名称】(R)-4-(3,4-Dichlorobenzamido)-5-[N-(3-methoxypropyl)-N-pentylamino]-5-oxopentanoic acid
      N2-(3,4-Dichlorobenzoyl)-N1-(3-methoxypropyl)-N1-pentyl-D-aspartic acid 1-amide

【CA登记号】119817-90-2

【 分 子 式 】C21H30Cl2N2O5

【 分 子 量 】461.38965

【开发单位】Rotta (Originator), Forest (Licensee)

【药理作用】Constipation, Agents for, Esophageal Diseases, Treatment of, Gastroesophageal Reflux Disease, Agents for, GASTROINTESTINAL DRUGS, Irritable Bowel Syndrome, Agents for, CCK1 (CCKA) Antagonists

合成路线1

The condensation of the N-(benzyloxycarbonyl)-D-glutamic acid 5-benzyl ester (I) with N-(3-methoxypropyl)-N-pentylamine (II) by means of ethyl chloroformate and triethylamine in THF gives the corresponding amide (III), which is debenzylated by hydrogenation over Pd/C in methanol, yielding compound (IV). Finally, the free amino group of (IV) is acylated with 3,4-dichlorobenzoyl chloride (V) by means of NaOH in water to give dexloxiglumide.

1 Castaner, J.; Revel, L.; Makovec, F.; Dexloxiglumide. Drugs Fut 1999, 24, 7, 725.
2 Makovec, F.; Chiste, R.; Peris, W.; Rovati, L. (Rotta Research Laboratorium SpA); Derivs. of (R)-5-pentylamino-5-oxopentanoic acid with anticholecystokinin activity. EP 0344184; JP 1988201156; US 5130474; US 5391574; WO 8805774 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 26353 (2R)-5-(benzyloxy)-2-[[(benzyloxy)carbonyl]amino]-5-oxopentanoic acid 5680-86-4 C20H21NO6 详情 详情
(II) 12130 N-(3-Methoxypropyl)-N-pentylamine; N-(3-Methoxypropyl)-1-pentanamine C9H21NO 详情 详情
(III) 26354 benzyl (4R)-4-[[(benzyloxy)carbonyl]amino]-5-[(3-methoxypropyl)(pentyl)amino]-5-oxopentanoate C29H40N2O6 详情 详情
(IV) 26355 benzyl (4R)-4-amino-5-[(3-methoxypropyl)(pentyl)amino]-5-oxopentanoate C21H34N2O4 详情 详情
(V) 26356 3,4-dichlorobenzoyl chloride 3024-72-4 C7H3Cl3O 详情 详情
Extended Information