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【结 构 式】 
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【药物名称】4-Iodopropofol 【化学名称】4-Iodo-2,6-diisopropylphenol 【CA登记号】169255-48-5 【 分 子 式 】C12H17IO 【 分 子 量 】304.17309 |
【开发单位】Cornell University (Originator), Università degli Studi di Bari (Originator), Università degli Studi di Cagliari (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Anesthetic Drugs, Anxiolytics, PSYCHOPHARMACOLOGIC DRUGS |
合成路线1
The title compound was obtained by iodination of 2,6-diisopropylphenol (propofol) (I) employing either potassium iodide and hydrogen peroxide or iodonium chloride in HOAc.
| 【1】 Altomare, C.; Latrofa, A.; Usala, M.; Sanna, E.; Liso, G.; Franco, M.; Biggio, G.; Trapani, G.; Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors. J Med Chem 1998, 41, 11, 1846. |
| 【2】 Bonal, J.; et al. (Bobel246 SL); Use derivatives of 2,4-bisubstituted phenols as 5-lipoxigenase inhibitors. WO 9521610 . |
Extended Information