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【结 构 式】 
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【药物名称】CX-546 【化学名称】1-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidine 【CA登记号】205510-63-0, 215923-54-9 【 分 子 式 】C14H17NO3 【 分 子 量 】247.29649 |
【开发单位】Cortex (Originator), University of California, Oakland (Originator) 【药理作用】Antipsychotic Drugs, Attention Deficit Hyperactivity Disorder (ADHD), Treatment of, PSYCHOPHARMACOLOGIC DRUGS, AMPA Receptor Modulators |
合成路线1
The title amide was prepared by coupling of 2,3-dihydrobenzodioxin-6-carboxylic acid (I) with piperidine (II). Carbonyldiimidazole or some chlorinating reagents, such as thionyl chloride or oxalyl chloride, were used as the carboxylate-activating reagents for the coupling reaction. Alternatively, acid (I) was previously converted to an activated mixed anhydride with either pivaloyl chloride or trifluoroacetic anhydride in the presence of triethylamine.
| 【1】 Van der Klish, P.; Lynch, G. (University of California, Oakland); Endocrine modulation with positive modulators of AMPA type glutamate receptors. US 6329368; WO 9850036 . |