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【结 构 式】 
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【药物名称】CFT, Win-35428 【化学名称】(-)-3beta-(4-Fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2beta-carboxylic acid methyl ester 【CA登记号】50370-56-4 【 分 子 式 】C16H20FNO2 【 分 子 量 】277.3417 |
【开发单位】National Institute on Drug Abuse (Originator), Research Triangle Institute (Originator), Sanofi-synthélabo (Originator) 【药理作用】Antagonists to Narcotics, Specific Antidotes, TREATMENT OF POISONING, DRUG ABUSE & DEPENDENCY |
合成路线1
By condensation of (-)-anhydroecgonine methyl ester (I) with 4-fluorophenylmagnesium bromide (II) by means of cuprous chloride in refluxing ether.
| 【1】 Clarke, R.L.; Daum, S.J.; US 3813404 . |
| 【2】 Clarke, R.L.; et al.; Compounds affecting the central nervous system. 4. 3beta-Phenyltropane-2-carboxylic esters and analogs. J Med Chem 1973, 16, 1, 1260-67. |
| 【3】 Castañer, J.; Hillier, K.; WIN-35,428. Drugs Fut 1980, 5, 9, 459. |
Extended Information