methyl 8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】39208

【品名】methyl 8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate

【CA登记号】

【分子式】C₁₀H₁₅NO₂

【分子量】181.23464

【元素组成】C 66.27% H 8.34% N 7.73% O 17.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

By condensation of (-)-anhydroecgonine methyl ester (I) with 4-fluorophenylmagnesium bromide (II) by means of cuprous chloride in refluxing ether.

【1】 Clarke, R.L.; Daum, S.J.; US 3813404 .
【2】 Clarke, R.L.; et al.; Compounds affecting the central nervous system. 4. 3beta-Phenyltropane-2-carboxylic esters and analogs. J Med Chem 1973, 16, 1, 1260-67.
【3】 Castañer, J.; Hillier, K.; WIN-35,428. Drugs Fut 1980, 5, 9, 459.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	39208	methyl 8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate		C₁₀H₁₅NO₂	详情	详情
(II)	13643	4-fluorophenyl magnesium bromide;Bromo(4-fluorophenyl)magnesium;bromo(p-fluorophenyl)Magnesium;p-Fluorophenylmagnesium bromide	352-13-6	C₆H₄BrFMg	详情	详情

Extended Information