K-12, -Drug Synthesis Database

【结构式】

【药物名称】K-12

【化学名称】8-(Difluoromethoxy)-1-ethyl-6-fluoro-7-[4-(2-methoxyphenyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

【CA登记号】153468-00-9

【分子式】C₂₄H₂₄F₃N₃O₅

【分子量】491.47118

【开发单位】Daiichi Pharmaceutical (Originator), Ube (Originator)

【药理作用】AIDS Medicines, Anti-HIV Agents, ANTIINFECTIVE THERAPY

合成路线1

By the usual method of synthesis of fluoroquinolones: By condensation of 8-(difluoromethoxy)-1-ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (I) with 1-(2-methoxyphenyl)piperazine (II) in pyridine.

参考文献中间体

【1】 Hagihara, M.; Kashiwase, H.; Ohmine, T.; Katsube, T.; Nishigaki, T.; Kimura, S.; Momota, K.; Komai, T.; Kimura, T.; Shimada, K.; Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: A new class of anti-HIV agents. Bioorg Med Chem Lett 1999, 9, 21, 3063.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	31084	8-(difluoromethoxy)-1-ethyl-6,7-difluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid		C₁₃H₉F₄NO₄	详情	详情
(II)	11882	1-(2-Methoxyphenyl)piperazine; Methyl 2-piperazinophenyl ether; 1-(2-Methoxyphenyl)-piperazine	35386-24-4	C₁₁H₁₆N₂O	详情	详情

Extended Information

FDA Approved Drug Products(4)