Leurubicin, E-88/032(hydrochloride), CT-012002, RP-39937, L-ADR, LEU-DOX, Doxogenix L, -Drug Synthesis Database

【结构式】

【药物名称】Leurubicin, E-88/032(hydrochloride), CT-012002, RP-39937, L-ADR, LEU-DOX, Doxogenix L

【化学名称】(8S,10S)-10-[[3-[(S)-2-Amino-4-methylvaleramido]-2,3,6-trideoxy-alphal-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
　　　　　　N-L-Leucyldoxorubicin
　　　　　　N-L-Leucyladriamycin
　　　　　　(8S-cis)-6,8,11-Trihydroxy-8-(hydroxyacetyl)-10-[2,3,6-trideoxy-3-(L-leucylamino)-alpha-L-lyxohexopyranosyloxy]-1-methoxy-5,8,9,10,12-hexahydronaphthacene-5,12-dione

【CA登记号】70774-25-3

【分子式】C₃₃H₄₀N₂O₁₂

【分子量】656.69295

【开发单位】Medgenix (Originator)

【药理作用】Antibiotics and Alkaloids, Antineoplastic Antibiotics, ONCOLYTIC DRUGS

合成路线1

By condensation of doxorubicin hydrochloride (I) with L-leucine N-carboxyanhydride (II) in a buffered aqueous solution at pH 10.2.

参考文献中间体

【1】 Baurain, R.; Trouet, A. (Medgenix Group); Novel doxorubicin derivs., process for their preparation and pharmaceutical compsns. BE 0869485; DE 2930637 .
【2】 Prous, J.; Castaner, J.; Leurubicin. Drugs Fut 1993, 18, 2, 116.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11675	(8S,10S)-10-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-8-glycoloyl-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-naphthacenedione		C₂₇H₂₉NO₁₁	详情	详情
(II)	14815	(4S)-4-isobutyl-1,3-oxazolane-2,5-dione	3190-70-3	C₇H₁₁NO₃	详情	详情

Extended Information