EF-4040, ME-3407, -Drug Synthesis Database

【结构式】

【药物名称】EF-4040, ME-3407

【化学名称】2-(Butoxycarbonylmethylsulfinyl)thiazolo[5,4-b]pyridine
　　　　　　2-(Thiazolo[5,4-b]pyridin-2-ylsulfinyl)acetic acid butyl ester

【CA登记号】133903-90-9

【分子式】C₁₂H₁₄N₂O₃S₂

【分子量】298.38498

【开发单位】Meiji Seika (Originator)

【药理作用】Antiulcer Drugs, Gastric Antisecretory Drugs, GASTROINTESTINAL DRUGS

合成路线1

2-Mercaptothiazolo[5,4-b]pyridine (I) is treated with chloroacetic acid butyl ester (II) in the presence of potassium carbonate in DMF to give 2-[(butoxycarbonylmethyl)thio]thiazolo[5,4-b]pyridine (III), which is oxidized with m-chloroperbenzoic acid in dichloromethane.

参考文献中间体

【1】 Katano, K.; Tomomoto, T.; Ogino, H.; Yamazaki, N.; Hirano, F.; Yuda, Y.; Konno, F.; Nishio, M.; Machinami, T.; Shibahara, S.; Tsuruoka, T.; Inouye, S. (Meiji Seika Kaisha, Ltd.); Azole derivs. and antiulcerative compsn. containing same. EP 0405976; JP 1991218377; US 5079255; US 5141946; US 5200407 .
【2】 Castaner, J.; Mealy, N.; Prous, J.; ME-3407. Drugs Fut 1994, 19, 1, 31.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14594	[1,3]thiazolo[5,4-b]pyridine-2-thiol; [1,3]thiazolo[5,4-b]pyridin-2-ylhydrosulfide		C₆H₄N₂S₂	详情	详情
(II)	14595	n-Butyl Chloroacetate; butyl 2-chloroacetate	590-02-3	C₆H₁₁ClO₂	详情	详情
(III)	14596	butyl 2-([1,3]thiazolo[5,4-b]pyridin-2-ylsulfanyl)acetate		C₁₂H₁₄N₂O₂S₂	详情	详情

Extended Information