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【结 构 式】 
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【药物名称】Andolast, CR-2039 【化学名称】4-(1H-Tetrazol-5-yl)-N-[4-(1H-tetrazol-5-yl)phenyl]benzamide 【CA登记号】132640-22-3 【 分 子 式 】C15H11N9O 【 分 子 量 】333.31462 |
【开发单位】Rotta (Originator) 【药理作用】Antiallergy/Antiasthmatic Drugs, Asthma Therapy, Drugs for Allergic Rhinitis, RESPIRATORY DRUGS, Treatment of Upper Respiratory Tract Disorders, Mediator Release Inhibitors |
合成路线1
Coupling between 4-cyanobenzoyl chloride (I) and 4-aminobenzonitrile (II) in the presence of Et3N afforded the corresponding amide (III). The dicyano compound (III) was then treated with sodium azide and ammonium chloride in hot DMF to produce the title bis-tetrazolyl derivative.
| 【1】 Makovec, F.; Peris, W.; Rovati, A.L. (Rotta Research Laboratorium SpA); Derivs. of N-phenylbenzamide with anti-ulcer and anti-allergy activity and a method for their preparation. EP 0460083; JP 1992503514; US 5232937; WO 9009989 . |
Extended Information