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【结 构 式】 
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【药物名称】Lobuprofen hydrochloride 【化学名称】2-[4-(m-Chlorophenyl)-1-piperazinyl]ethyl (±)-p-isobutylhydratropate hydrochloride 【CA登记号】96128-90-4 (free base) 【 分 子 式 】C25H34Cl2N2O2 【 分 子 量 】465.46793 |
【开发单位】Juste (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Non-Opioid Analgesics |
合成路线1
1) The condensation of a phenylpiperazine (I) with chloroethanol (II) gives compound (III) which, upon reaction with the acid chloride (IV), yields lobuprofen.
| 【1】 Alamo Gonzalez, C.; Carretero Colon, J.M.; Martin Jimenez, J.L. (Juste, SA Quimico-Farmaceutica); Novel phenylpiperazine derivs., process for prepar. EP 0141884 . |
| 【2】 Carretero, J.M.; Alamo, C.; Martin, J.L.; Lobuprofen hydrochloride. Drugs Fut 1988, 13, 4, 314. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22114 | 1-(3-chlorophenyl)piperazine | 6640-24-0 | C10H13ClN2 | 详情 | 详情 |
| (II) | 10384 | 2-Chloro-1-ethanol; Ethylene chlorohydrin | 107-07-3 | C2H5ClO | 详情 | 详情 |
| (III) | 22116 | 2-[4-(3-chlorophenyl)-1-piperazinyl]-1-ethanol | C12H17ClN2O | 详情 | 详情 | |
| (IV) | 22117 | 2-(4-isobutylphenyl)propanoyl chloride | C13H17ClO | 详情 | 详情 |
合成路线2
2) The acid chloride (IV) is reacted with chloroethanol to give compound (V), which, upon condensation with a piperazine (I), yields lobuprofen.
| 【1】 Alamo Gonzalez, C.; Carretero Colon, J.M.; Martin Jimenez, J.L. (Juste, SA Quimico-Farmaceutica); Novel phenylpiperazine derivs., process for prepar. EP 0141884 . |
| 【2】 Prous, J.; Castaner, J.; ONO-RS-411. Drugs Fut 1988, 13, 4, 317. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22114 | 1-(3-chlorophenyl)piperazine | 6640-24-0 | C10H13ClN2 | 详情 | 详情 |
| (II) | 10384 | 2-Chloro-1-ethanol; Ethylene chlorohydrin | 107-07-3 | C2H5ClO | 详情 | 详情 |
| (IV) | 22117 | 2-(4-isobutylphenyl)propanoyl chloride | C13H17ClO | 详情 | 详情 | |
| (V) | 22118 | 2-chloroethyl 2-(4-isobutylphenyl)propanoate | C15H21ClO2 | 详情 | 详情 |