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【结 构 式】 
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【药物名称】Piberaline fumarate, EGYT-475, Trelibet 【化学名称】1-Phenylmethyl-4-(2-pyridylcarbonyl)piperazine (E)-2-butenedioate (1:1) 【CA登记号】39640-14-7, 39640-12-5 (diHCl), 39640-15-8 (free base) 【 分 子 式 】C21H23N3O5 【 分 子 量 】397.43456 |
【开发单位】Egis (Originator) 【药理作用】Antidepressants, Mood Disorders, Treatment of, PSYCHOPHARMACOLOGIC DRUGS |
合成路线1
This compound can be obtained in three different ways: 1) Condensation of pyridine-2-carboxylic acid (Ia, R = H), with 1-phenyl methylpiperazine (II) at 160 C. 2) Condensation of methyl pyridine-2-carboxylate (Ib, R = CH3) with 1-phenylmethylpiperazine (II) at 140 C. 3) Reaction of 1-phenylmethylpiperazine (II) with a mixed anhydride (III) formed from (Ia) and ethyl chloroformate (IV).
| 【1】 Budai, Z.; Zolyomi, G.; Synthesis of 14C and 3H specifically labelled 1-benzyl-4-picolinoylpiperazine. J Label Compd Radiopharm 1981, 18, 427-432. |
| 【2】 Budai, Z.; Mezei, T.; Lay, A.; A novel synthesis of pyridinecarboxylic acid piperazides. Acta Chim Acad Sci Hung 1980, 105, 241-246. |
| 【3】 Budai, Z.; Mezei, T.; Lay, A. (Egis Pharmaceuticals Ltd.); Preparation of pyridinecaboxylic acid piperazides. DE 2828888; GB 2001062; HU 175075 . |
| 【4】 Korosi, J.; et al. (Egis Pharmaceuticals Ltd.); Pyridine derivatives. DE 2215545; GB 1378964; HU 162396; JP 7644957 . |
| 【5】 Nogradi, M.; Piberaline. Drugs Fut 1984, 9, 1, 30. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (Ia) | 29950 | 2-pyridinecarboxylic acid；picolinic acid;Pyridine-2-carboxylic acid | 98-98-6 | C6H5NO2 | 详情 | 详情 |
| (Ib) | 29951 | methyl 2-pyridinecarboxylate | 2459-07-6 | C7H7NO2 | 详情 | 详情 |
| (II) | 28542 | N-Benzylpiperazine; 1-Benzylpiperazine | 2759-28-6 | C11H16N2 | 详情 | 详情 |
| (III) | 29952 | ethyl 2-oxo-2-(2-pyridinyl)acetate | C9H9NO3 | 详情 | 详情 | |
| (IV) | 11229 | 1-[(Chlorocarbonyl)oxy]ethane;ethyl carbonochloridate; Carbonchloridic acid ethyl ester;Ethyl chloroformate;Ethyl chlorocarbonate | 541-41-3 | C3H5ClO2 | 详情 | 详情 |