Doxofylline, DO-309, ABC-1213, ABC-12/3, Maxivent, Ventax, Ansimar, -Drug Synthesis Database

【结构式】

【药物名称】Doxofylline, DO-309, ABC-1213, ABC-12/3, Maxivent, Ventax, Ansimar

【化学名称】2-(7'-Theophyllinemethyl)-1,3-dioxolane
　　　　　　7-(1,3-Dioxolan-2-ylmethyl)theophylline
　　　　　　7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

【CA登记号】69975-86-6

【分子式】C₁₁H₁₄N₄O₄

【分子量】266.25863

【开发单位】Istituto Biologico Chemioterapico ABC (Originator)

【药理作用】Asthma Therapy, Bronchodilators, RESPIRATORY DRUGS, Adenosine A1 Antagonists, Methylxanthines

合成路线1

By reaction of theophylline-7-acetaldehyde (I) with ethylene glycol (II) by means of p-toluenesulfonic acid in refluxing benzene.

参考文献中间体

【1】 De Martiis, F.; Toffoli, F.; Avico, U.; Diossolani ed 1,3-diossani. Farm Sci Ed 1962, 17, 73-80.
【2】 Franzone, J.S.; Di Carlo, R.; Fonzo, D.; Reboani, C.; Pharmacoligical researches on 2-(7'-theophyllinemethyl)-1,3-dioxolane. Farm Sci Ed 1981, 36, 201-219.
【3】 Franzone, J.S.; Tamietto, T. (Istituto Biologico Chemioterapico "ABC" SpA); Pharmaceutical composition with anti-bronchospasmodic and anti-tussive activity. BE 0868556; DE 2827497; FR 2421614; GB 1582510; JP 1123066C; JP 54138127; JP 57015088B; NL 7807152; US 4187308 .
【4】 Dowle, M.D.; Wu, W.-Y.; Jin, B.; Mason, A.M.; McConnell, D.; MacDonald, S.J.F.; Shanahan, S.E.; Nguyen, V.T.T. (Biota Scientific Management Pty Ltd.); Dimeric cpds. and their use as anti-viral agents. WO 0340135 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	31948	2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetaldehyde; theophylline-7-acetaldehyde	5614-53-9	C₉H₁₀N₄O₃	详情	详情
(II)	11295	Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol	107-21-1	C₂H₆O₂	详情	详情

Extended Information