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【结 构 式】 
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【分子编号】31948 【品名】2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetaldehyde; theophylline-7-acetaldehyde 【CA登记号】5614-53-9 |
【 分 子 式 】C9H10N4O3 【 分 子 量 】222.20356 【元素组成】C 48.65% H 4.54% N 25.21% O 21.6% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)By reaction of theophylline-7-acetaldehyde (I) with ethylene glycol (II) by means of p-toluenesulfonic acid in refluxing benzene.
| 【1】 De Martiis, F.; Toffoli, F.; Avico, U.; Diossolani ed 1,3-diossani. Farm Sci Ed 1962, 17, 73-80. |
| 【2】 Franzone, J.S.; Di Carlo, R.; Fonzo, D.; Reboani, C.; Pharmacoligical researches on 2-(7'-theophyllinemethyl)-1,3-dioxolane. Farm Sci Ed 1981, 36, 201-219. |
| 【3】 Franzone, J.S.; Tamietto, T. (Istituto Biologico Chemioterapico "ABC" SpA); Pharmaceutical composition with anti-bronchospasmodic and anti-tussive activity. BE 0868556; DE 2827497; FR 2421614; GB 1582510; JP 1123066C; JP 54138127; JP 57015088B; NL 7807152; US 4187308 . |
| 【4】 Dowle, M.D.; Wu, W.-Y.; Jin, B.; Mason, A.M.; McConnell, D.; MacDonald, S.J.F.; Shanahan, S.E.; Nguyen, V.T.T. (Biota Scientific Management Pty Ltd.); Dimeric cpds. and their use as anti-viral agents. WO 0340135 . |
Extended Information