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【结 构 式】 
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【药物名称】Flurbiprofen axetil, FP-83, Ropion 【化学名称】(±)-2-(2-Fluoro-4-biphenylyl)propionic acid 1-(acetoxy)ethyl ester 【CA登记号】91503-79-6 【 分 子 式 】C19H19FO4 【 分 子 量 】330.35928 |
【开发单位】Kaken (Originator), Mitsubishi Pharma (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Non-Opioid Analgesics, Non-Steroidal Antiinflammatory Drugs |
合成路线1
By esterification of 2-(2-fluoro-4-biphenylyl)propionic acid (I) with 1-(acetoxy)ethyl chloride (II) or 1-(acetoxy)ethyl bromide (III) by means of anhydrous K2CO3 in DMF or by transesterification of the acid (I) and ethylidene diacetate (IV) in benzene.
| 【1】 Mimura, M.; Uchida, K.; Ieda, T.; et al.; Method for the preparation of 1-acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate. JP 89211550 . |
| 【2】 Uchida, K.; Masumoto, S.; Tohno, M.; Mimura, M.; Okumura, M.; Ichikawa, K.; Matsumura, M. (Kaken Pharmaceutical Co., Ltd.); Biphenylpropionic acid deriv., process for preparing the same and pharmaceutical compsn. containing the same. EP 0103265; US 5196567 . |
| 【3】 Mizushima, Y.; Uchida, K.; Masumoto, S.; Tohno, M.; Hashimoto, Y.; Yokoyama, K.; Okamoto, H.; Nabeta, K.; Suyama, T. (Welfide Corporation); Ester of flurbiprofen and emulsion containing the same. EP 0129435; JP 1985001122; US 4613505 . |
| 【4】 Prous, J.; Castaner, J.; Liposomal Flurbiprofen Axetil. Drugs Fut 1992, 17, 9, 788. |
Extended Information