1-chloroethyl acetate -Drug Synthesis Database

【结构式】

【分子编号】12281

【品名】1-chloroethyl acetate

【CA登记号】

【分子式】C₄H₇ClO₂

【分子量】122.55108

【元素组成】C 39.2% H 5.76% Cl 28.93% O 26.11%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

By esterification of 2-(2-fluoro-4-biphenylyl)propionic acid (I) with 1-(acetoxy)ethyl chloride (II) or 1-(acetoxy)ethyl bromide (III) by means of anhydrous K2CO3 in DMF or by transesterification of the acid (I) and ethylidene diacetate (IV) in benzene.

参考文献中间体

合成目标

【1】 Mimura, M.; Uchida, K.; Ieda, T.; et al.; Method for the preparation of 1-acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate. JP 89211550 .
【2】 Uchida, K.; Masumoto, S.; Tohno, M.; Mimura, M.; Okumura, M.; Ichikawa, K.; Matsumura, M. (Kaken Pharmaceutical Co., Ltd.); Biphenylpropionic acid deriv., process for preparing the same and pharmaceutical compsn. containing the same. EP 0103265; US 5196567 .
【3】 Mizushima, Y.; Uchida, K.; Masumoto, S.; Tohno, M.; Hashimoto, Y.; Yokoyama, K.; Okamoto, H.; Nabeta, K.; Suyama, T. (Welfide Corporation); Ester of flurbiprofen and emulsion containing the same. EP 0129435; JP 1985001122; US 4613505 .
【4】 Prous, J.; Castaner, J.; Liposomal Flurbiprofen Axetil. Drugs Fut 1992, 17, 9, 788.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12280	Flurbiprofen; 2-(2-Fluoro[1,1'-biphenyl]-4-yl)propionic acid	5104-49-4	C₁₅H₁₃FO₂	详情	详情
(II)	12281	1-chloroethyl acetate		C₄H₇ClO₂	详情	详情
(III)	12282	1-bromoethyl acetate		C₄H₇BrO₂	详情	详情
(IV)	31254	1-(acetoxy)ethyl acetate	542-10-9	C₆H₁₀O₄	详情	详情

Extended Information