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【结 构 式】 
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【药物名称】Icoduline hydrochloride, CBS-113 A 【化学名称】2-(2-Hydroxy-4-methylphenylamino)thiazole hydrochloride 【CA登记号】110952-54-0, 138511-81-6 (free base) 【 分 子 式 】C10H11ClN2OS 【 分 子 量 】242.72897 |
【开发单位】Chauvin (Originator) 【药理作用】Antiinflammatory Ophthalmic Agents, Ocular Antiinflammatory and Antiinfective Agents, OCULAR MEDICATIONS, Ophthalmic Drugs |
合成路线1
Condensation of benzoil isothiocyanate (I) with 6-amino-m-cresol in refluxing acetone gives N-benzoyl-N'-(2-hydroxy-4-methylphenyl)thiourea (II), which is hydrolyzed with sodium hydroxide to afford N-(2-hydroxy-4-methyl(phenyl)thiourea (III). Thiazolyl ring closure is obtained by addition of chloroacetaldehyde diethylacetal in refluxing ethanol catalyzed by p-toluenesulfonic acid. 2-(2-Hydroxy-4-methylphenyl)aminothiazole is then converted to its hydrochloride sait by bubbling gaseous hydrochloric acid.
| 【1】 Alazet, A.; Bonne, C.; Coquelet, C.; Sincholle, D. (Chauvin Laboratories SA); N-Substd. 2-amino-thiazoles, process for their pre. EP 0202157; ES 8900045; FR 2581063; JP 1987077375; US 4785008 . |
| 【2】 Coquelet, C.; Bonne, C.; CBS-113 A. Drugs Fut 1987, 12, 6, 525. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 63311 | 2-chloro-1-ethoxyethyl ethyl ether; 2-chloro-1,1-diethoxyethane | C6H13ClO2 | 详情 | 详情 | ||
| (A) | 23533 | 2-amino-5-methylphenol | 2835-98-5 | C7H9NO | 详情 | 详情 |
| (I) | 23530 | benzoyl isothiocyanate | 532-55-8 | C8H5NOS | 详情 | 详情 |
| (II) | 23531 | N-benzoyl-N'-(2-hydroxy-4-methylphenyl)thiourea | C15H14N2O2S | 详情 | 详情 | |
| (III) | 23532 | N-(2-hydroxy-4-methylphenyl)thiourea | C8H10N2OS | 详情 | 详情 |