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【结 构 式】 
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【药物名称】Miriplatin, SMP-11355, SM-11355, DACHPM, DACHPt(II)(Myr)2 【化学名称】(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kappaN,kappaN'])bis(myristato-kappaO)platinum(II) 【CA登记号】141977-79-9 【 分 子 式 】C34H68N2O4Pt 【 分 子 量 】764.02206 |
【开发单位】Sumitomo Pharmaceuticals (Originator) 【药理作用】Liver Cancer Therapy, Oncolytic Drugs, DNA Alkylating Drugs, Platinum Complexes |
合成路线1
Dichlorocyclohexane-1,2-diamine platinum complex (II) was prepared from (R,R)-1,2-cyclohexanediamine (I) according to a known method. Subsequent treatment of (II) with aqueous silver nitrate produced the diaqua complex (III). Finally, displacement of H2O by means of sodium myristate (IV) gave rise to the title compound.
| 【1】 Maeda, M.; Sasaki, T. (Sumitomo Pharmaceuticals Co., Ltd.); Liposoluble platinum (II) complex and preparation thereof. AU 8654358; EP 0193936; JP 1987000096 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11130 | (1R,2R)-1,2-cyclohexanediamine; (1R,2R)-2-aminocyclohexylamine; cis-1,2-Diaminocyclohexane | 20439-47-8 | C6H14N2 | 详情 | 详情 |
| (II) | 23063 | (R,R)-Cyclohexane-1,2-diamine dichloro platinum complex | C6H14Cl2N2Pt | 详情 | 详情 | |
| (III) | 40706 | C6H14Cl2N4O6Pt | 详情 | 详情 | ||
| (IV) | 40707 | sodium myristate | 822-12-8 | C14H27NaO2 | 详情 | 详情 |
Extended Information