MPTP, NSC 139654, -Drug Synthesis Database

【结构式】

【药物名称】MPTP, NSC 139654

【化学名称】1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

【CA登记号】28289-54-5

【分子式】C₁₂H₁₅N

【分子量】173.26005

【开发单位】Aldrich (Supplier)

【药理作用】PHARMACOLOGICAL TOOLS

合成路线1

The reaction of N-methyl-4-piperidone (II) with phenyllithium (I) in benzene-ethyl ether below 10 C gives 4-hydroxy-1-methyl-4.phenypiperidine (III), which is dehydrated by treating with refuxing concentrated HCl.

参考文献中间体

【1】 Frank, M.; Clarke, H.Jr. (Novartis Corp.); Nouveaux benzomorphanes et leur preparation. DE 1445845; DE 1795599; FR 1440638; FR 4024M; GB 1050227; US 3320265 .
【2】 Block, F.B.; et al. (Novartis Corp.); Certain 2,6-methano-3-benzazocines. US 3341538 .
【3】 Castaner, J.; Prous, J.; MPTP. Drugs Fut 1986, 11, 5, 384.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	24014	Phenyllithium	591-51-5	C₆H₅Li	详情	详情
(II)	10919	1-Methyl-4-piperidone; 1-Methyltetrahydro-4(1H)-pyridinone; N-Methyl-4-piperidone;1-methylpiperidin-4-one	1445-73-4	C₆H₁₁NO	详情	详情
(III)	24016	1-methyl-4-phenyl-4-piperidinol		C₁₂H₁₇NO	详情	详情

Extended Information