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【结 构 式】 
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【药物名称】Licarbazepine, MHD, TRI-477, GP-47779 【化学名称】(±)-10-Hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide 【CA登记号】29331-92-8 【 分 子 式 】C15H14N2O2 【 分 子 量 】254.29103 |
【开发单位】Novartis (Originator) 【药理作用】Antiepileptic Drugs, NEUROLOGIC DRUGS, Sodium Channel Blockers |
合成路线1
Reaction of 10-methoxy-5H-dibenzo[b,f]azepine (I) with phosgene in toluene produced the dibenzoazepine-5-carbonyl chloride (II). This was converted to urea (III) upon treatment with ethanolic ammonia. Acidic hydrolysis of the enol ether function of (III) afforded ketone (IV). Then, reduction of the ketone (IV) to the target alcohol was accomplished either by catalytic hydrogenation over copper chromite or by means of NaBH4 in aqueous EtOH.
| 【1】 Garrett, J.; Soares-da-Silva, P.; Freitas, A.P.; Cunha, R.A.; Benes, J.; Parada, A.; Learmonth, D.A.; Alves, P.C.; Figueiredo, A.; Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J Med Chem 1999, 42, 14, 2582. |
| 【2】 Schindler, W. (Novartis AG); Process for the preparation of a new azepine deriv.. DE 2011045; GB 1310120 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24333 | 10-methoxy-5H-dibenzo[b,f]azepine;10-Methoxyiminostilbene | 4698-11-7 | C15H13NO | 详情 | 详情 |
| (II) | 24334 | 10-methoxy-5H-dibenzo[b,f]azepine-5-carbonyl chloride | C16H12ClNO2 | 详情 | 详情 | |
| (III) | 24335 | 10-methoxy-5H-dibenzo[b,f]azepine-5-carboxamide | C16H14N2O2 | 详情 | 详情 | |
| (IV) | 33774 | 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide | 28721-07-5 | C15H12N2O2 | 详情 | 详情 |
合成路线2
The title compound has also been obtained from microbiological hydroxylation of 10,11-dihydrocarbamazepine (V) using several species of the genus Streptomyces.
| 【1】 Kittelmann, M.; et al.; Preparation of 10,11-epoxy-carbamazepine and 10,11-dihydro-10-hydroxy-carbamazepine by microbial epoxidation and hydroxylation. Biosci Biotechnol Biochem 1993, 57, 9, 1589. |