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【结 构 式】 
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【药物名称】Tibolone, KB-889, Org-OD14, Xyvion, Boltin, Livial 【化学名称】7alpha-Methyl-17alpha-ethynyl-17beta-hydroxy-19-norandrost-5(10)-en-3-one 【CA登记号】5630-53-5 【 分 子 式 】C21H28O2 【 分 子 量 】312.45611 |
【开发单位】Organon (Originator), Kanebo (Licensee) 【药理作用】Bone Diseases, Treatment of, Breast Cancer Therapy, Disorders of Sexual Function and Reproduction, Treatment of, ENDOCRINE DRUGS, Gynecological Disorders, Treatment of , METABOLIC DRUGS, Oncolytic Drugs, Prevention of Osteoporosis, Treatment of Female Sexual Dysfunction, Treatment of Osteoporosis, Treatment of Postmenopausal Syndrome , Androgens, Steryl Sulfatase Inhibitors |
合成路线1
By condensation of 7-methyl-3,17,19-trioxo-DELTA4-androstene (I) with acetylene by means of potassium in liquid ammonia.
| 【1】 Solomon, M.; Harryvan, E.A.; Process for the preparation of delta[5,(10)]-3-keto-19-nor-steroids. BE 0700390; DE 1618747; FR 1527563; GB 1177845; US 3475465 . |
| 【2】 Castaner, J.; Serradell, M.N.; Blancafort, P.; Hillier, K.; Tibolone. Drugs Fut 1981, 6, 5, 302. |
Extended Information