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【结 构 式】 
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【药物名称】Cycloplatam 【化学名称】(S)-(-)Malatoammine(cyclopentylamine)platinum (II) 【CA登记号】106356-80-3 ((SP-4-3)-isomer), 106356-84-7 ((SP-4-4)-isomer), 106283-21-0 ([SP-4-3-(S)]-isomer), 106356-83-6 ([SP-4-4(S)]-isomer 【 分 子 式 】C9H18N2O5Pt 【 分 子 量 】429.34421 |
【开发单位】Inst. Obs. Neorg. Khim. Imeni (Originator), Russian Academy of Medical Sciences (Originator), Vse. Onkol. Nauch. Tsentr Ak. (Originator) 【药理作用】Oncolytic Drugs, Platinum Complexes, Protein Kinase C (PKC) Inhibitors |
合成路线1
Treatment of cyclopentylamine (I) with potassium trichloroaminoplatinate and potassium iodide in H2O provides a mixture of platinum complexes (II) and (III), which is then subjected to reaction with silver (S)-(-)-malate (IV) in H2O to furnish the desired platinum complex.
| 【1】 Cheltsov-Bebutov, P.A.; Kravchenko, A.N.; Schelokov, R.N.; Konovalova, A.L.; Presnov, M.A.; Ivanov, V.B. (Inst. Obs. Neorg. Khim. Imeni; Vse. Onkol. Nauch. Tsentr Ak.); Carboxylatoplatinum(II) complexes and process for their preparation. FR 2563524 . |