Octenidine hydrochloride, Win-414642, -Drug Synthesis Database

【结构式】

【药物名称】Octenidine hydrochloride, Win-414642

【化学名称】1,1'-(Decane-1,10-diiyl)bis[4-(octylimino)-1,4-dihydropyridine] dihydrochloride

【CA登记号】70775-75-6, 71251-02-0 (free base)

【分子式】C₃₆H₆₄Cl₂N₄

【分子量】623.84428

【开发单位】Sanofi-synthélabo (Originator)

【药理作用】Antibacterial Drugs, Antidiarrheal Agents, ANTIINFECTIVE THERAPY, DENTAL AGENTS, Dermatologic Drugs, GASTROINTESTINAL DRUGS

合成路线1

The condensation of octylamine (I) with 4-bromopyridine by heating at 180 C gives (4-octylamino)piridine (III), which is then allowed to react with 1,10-dichlorodecane by heating 120-80 C.

参考文献中间体

【1】 Bailey, D.M.; et al.; Bispyridinamines: A new class of topical antimicrobial agents as inhibitors of dental plaque. J Med Chem 1984, 27, 11, 1457.
【2】 Castaner, J.; Pento, J.T.; Octenidine hydrochloride. Drugs Fut 1986, 11, 4, 269.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	27374	1-octanamine	111-86-4	C₈H₁₉N	详情	详情
(II)	23565	4-bromopyridine	1120-87-2	C₅H₄BrN	详情	详情
(III)	31346	N-octyl-4-pyridinamine; N-octyl-N-(4-pyridinyl)amine		C₁₃H₂₂N₂	详情	详情
(IV)	27376	1,10-dichlorodecane	2162-98-3	C₁₀H₂₀Cl₂	详情	详情

Extended Information