Zorubicin hydrochloride, NSC-164011, RP-22050, Rubidazone, -Drug Synthesis Database

【结构式】

【药物名称】Zorubicin hydrochloride, NSC-164011, RP-22050, Rubidazone

【化学名称】2-Benzoylhydrazone of daunorubicin hydrochloride
　　　　　　(2S-cis)-Benzoic acid [1-[4-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide hydrochloride
　　　　　　4-Methoxy-5,7,8,9,10,12-hexahydro-5,12-dioxo-6,9,11-trihydroxy-7-[2,3,6-trideoxy-3-amino-L-lyxo-hexosyl-(1)-oxy]-9-(2-benzoylhydrazonoethyl)naphthacene hydrochloride

【CA登记号】36508-71-1, 54083-22-6 (free base)

【分子式】C₃₄H₃₆ClN₃O₁₀

【分子量】682.13312

【开发单位】Aventis Pharma (Originator)

【药理作用】Antibiotics and Alkaloids, Antineoplastic Antibiotics, Leukemia Therapy, ONCOLYTIC DRUGS

合成路线1

By condensation of daunorubicin-HCl (I) with benzoylhydrazine (II) by means of acetic acid in ethanol at 60 C.

参考文献中间体

【1】 Jolles, G.; Neue Naphthacenderivate und ihre Herstellung. DE 2327211 .
【2】 Castaner, J.; Woodman, R.J.; Zorubicin. Drugs Fut 1979, 4, 1, 61.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18698	7-(3-Amino-2,3,6-trideoxy-L-lyxo-hexosyloxy)-9-acetyl-7,8,9,10-tetrahydro-6,9,11-trihydroxy-4-methoxy-5,12-naphthacenequinone; (8S,10S)-8-acetyl-10-[[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydro-5,12-naphthacenedione; (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-lyxo-hexopyranoside; Daunomycin	20830-81-3	C₂₇H₂₉NO₁₀	详情	详情
(II)	33310	benzoylhydrazine; benzhydrazide; benzohydrazide	613-94-5	C₇H₈N₂O	详情	详情

Extended Information