Febuprol, K-10033, Valbil, -Drug Synthesis Database

【结构式】

【药物名称】Febuprol, K-10033, Valbil

【化学名称】1-Butoxy-3-phenoxy-2-propanol
　　　　　　(3-n-Butoxy-2-hydroxypropyl)phenyl ether

【CA登记号】3102-00-9

【分子式】C₁₃H₂₀O₃

【分子量】224.30255

【开发单位】Fujisawa Deutschland (Originator)

【药理作用】Cholagogues, Gallstone-Dissolving Agents, GASTROINTESTINAL DRUGS, Liver and Biliary Tract Disorders, Treatment of

合成路线1

1) By condensation of phenol (I) with 1-n-butoxy-2,3-epoxypropane (VII) in presence of potassium hydroxide. 2) By condensation of phenol (I) with 1-chloro-2,3-epoxypropane (II) followed either by addition of n-butanol (VI) in presence of a Lewis acid or in presence of a base (IV).

参考文献中间体

【1】 Hoffmann, H.; et al.; Procedimiento de fabricacion de sustancias medicinalmente activas y metodo de preparacion de medicamentos de accion coleretica. ES 402799; FR 2134389; GB 1393451; US 3839587 .
【2】 Janiak, P. St.; Febuprol. Drugs Fut 1978, 3, 3, 191.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23540	Phenol	108-95-2	C₆H₆O	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	33456	1-chloro-3-phenoxy-2-propanol		C₉H₁₁ClO₂	详情	详情
(IV)	33457	sodium 1-butanolate; Sodium butoxide; Sodium n-butoxide	2372-45-4	C₄H₉NaO	详情	详情
(V)	23932	2-(phenoxymethyl)oxirane; oxiranylmethyl phenyl ether	122-60-1	C₉H₁₀O₂	详情	详情
(VI)	29766	butanol; n-butanol; 1-butanol	71-36-3	C₄H₁₀O	详情	详情
(VII)	33458	2-(butoxymethyl)oxirane; butyl 2-oxiranylmethyl ether	2426-08-6	C₇H₁₄O₂	详情	详情

Extended Information