Butoctamide hemisuccinate, Listomin, -Drug Synthesis Database

【结构式】

【药物名称】Butoctamide hemisuccinate, Listomin

【化学名称】N-(2-Ethylhexyl)-3-hydroxybutyramide hydrogen succinate
　　　　　　N-2-Ethylhexyl-beta-hydroxybutyramide hydrogen succinate
　　　　　　N-(2-Ethylhexyl)-3-hydroxybutanamide hydrogen succinate

【CA登记号】32838-28-1

【分子式】C₁₆H₂₉NO₅

【分子量】315.41323

【开发单位】Banyu (Originator), Merck & Co. (Originator)

【药理作用】PSYCHOPHARMACOLOGIC DRUGS, Sedative/Hypnotics, Sleep Disorders, Treatment of

合成路线1

The reaction of diketene (I) with 2-ethylhexylamine (II) gives N-(2-ethylhexyl)acetoacetamide (III), which is reduced to the target compound with H2 over Raney-Ni in methanol.

参考文献中间体

【1】 Yamagisawa, I.; Torii, S.; Sakuma, A. (Lion Corp.); N-Substd.-beta-oxybutyramide semisuccinate and its salt having effects of increasing paradoxical sleep and tranquillizing. DE 1768445; US 3639457 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11367	4-Methylene-2-oxetanone; Acetyl ketene	674-82-8	C₄H₄O₂	详情	详情
(II)	31410	2-ethylhexylamine; 2-ethyl-1-hexanamine	104-75-6	C₈H₁₉N	详情	详情
(III)	31411	N-(2-ethylhexyl)-3-oxobutanamide	32837-36-8	C₁₂H₂₃NO₂	详情	详情

Extended Information