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【结 构 式】 
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【药物名称】Ticlopidine hydrochloride, 4-C-32, 53-32C, Panaldine, Tiklyd, Tiklid, Ipaton, Ticlodone, Ticlodix, Ticlid 【化学名称】5-[(2-Chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride 【CA登记号】53885-35-1, 55142-85-3 (free base) 【 分 子 式 】C14H15Cl2NS 【 分 子 量 】300.25235 |
【开发单位】Roche Bioscience (Originator), Sanofi-synthélabo (Originator), Daiichi Pharmaceutical (Not Determined), Egis (Not Determined), Almirall Prodesfarma (Licensee) 【药理作用】Antiplatelet Therapy, CARDIOVASCULAR DRUGS, Cerebrovascular Diseases, Treatment of, Coagulation Disorders Therapy, HEMATOLOGIC DRUGS, NEUROLOGIC DRUGS, Stroke, Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis |
合成路线1
By condensation of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine (I) and 2-chlorobenzyl chloride (II) with K2CO3 in refluxing ethanol or by reaction of thieno[3,2-c]pyridine (III) with 2-chlorobenzyl chloride (II) in refluxing acetonitrile to give the thienopyridinium salt (IV), which is then reduced with NaBH4 in ethanol-water.
| 【1】 Eloy, F.; Maffrand, J.P.; Synthese d thienopyridines et de furopyridines d'interet therapeutique. Eur J Med Chem 1974, 9, 483. |
| 【2】 Castaner, J.; Arrigoni-Martelli, E.; Ticlopidine. Drugs Fut 1976, 1, 4, 190. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 34011 | 4,5,6,7-tetrahydrothieno[3,2-c]pyridine | 54903-50-3 | C7H9NS | 详情 | 详情 |
| (II) | 10205 | 1-Chloro-2-(chloromethyl)benzene; 2-Chlorobenzyl chloride | 611-19-8 | C7H6Cl2 | 详情 | 详情 |
| (III) | 34010 | thieno[3,2-c]pyridine | C7H5NS | 详情 | 详情 | |
| (IV) | 34009 | 5-(2-chlorobenzyl)thieno[3,2-c]pyridin-5-ium chloride | C14H11Cl2NS | 详情 | 详情 |