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【结 构 式】 
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【药物名称】Sch-28080 【化学名称】2-Methyl-8-benzyloxyimidazo[1,2-a]pyridine-3-acetonitrile 【CA登记号】76081-98-6 【 分 子 式 】C17H15N3O 【 分 子 量 】277.3286 |
【开发单位】Schering-Plough (Originator) 【药理作用】Antiulcer Drugs, GASTROINTESTINAL DRUGS, H+/K+-ATPase Inhibitors |
合成路线1
By cyclization of 2-amino-3-benzyloxypyridine (I) with 3-chloro-4-oxopentanonitrile (II) by means of thiethylamine in ethanol. Compound (I) is prepared by benzylation of 2-amino-3-hydroxypyridine (III) with benzyl chloride (IV) by means of NaOH in water-CH2Cl2. Compound (II) is prepared by chlorination of 4-oxopentanonitrile (V) with SO2Cl2 in ether.
| 【1】 Puchalski, C.; Bristol, J.A.; EP 0033094 . |
| 【2】 Hillier, K.; Serradell, M.N.; Castaner, J.; Blancafort, P.; SCH-28,080. Drugs Fut 1982, 7, 10, 755. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37087 | 3-(benzyloxy)-2-pyridinylamine; 3-(benzyloxy)-2-pyridinamine | 24016-03-3 | C12H12N2O | 详情 | 详情 |
| (II) | 37089 | 3-chloro-4-oxopentanenitrile | C5H6ClNO | 详情 | 详情 | |
| (III) | 37086 | 2-amino-3-pyridinol; 2-Amino-3-hydroxypyridine | 16867-03-1 | C5H6N2O | 详情 | 详情 |
| (IV) | 19171 | 1-(Chloromethyl)benzene; Benzyl chloride | 100-44-7 | C7H7Cl | 详情 | 详情 |
| (V) | 37088 | 4-oxopentanenitrile | C5H7NO | 详情 | 详情 |
Extended Information