Nafimidone hydrochloride, RS-81943, -Drug Synthesis Database

【结构式】

【药物名称】Nafimidone hydrochloride, RS-81943

【化学名称】2-Imidazol-1-yl-2'-acetonaphthone hydrochloride
　　　　　　1-(2-Naphthoylmethyl)imidazole hydrochloride
　　　　　　2-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone hydrochloride

【CA登记号】70891-37-1, 64212-22-2 (free base), 64212-23-3 (mononitrate)

【分子式】C₁₅H₁₃ClN₂O

【分子量】272.73666

【开发单位】Roche Bioscience (Originator)

【药理作用】Antiepileptic Drugs, NEUROLOGIC DRUGS

合成路线1

By reaction of 2-naphthyl bromomethyl ketone (I) with imidazole (II) in DMF, followed by a treatment with HCl in ether.

参考文献中间体

【1】 Walker, K.A.M.; GB 1540023 .
【2】 Hirschfeld, D.R.; Walker, K.A.M.; Wallach, M.B.; 1-(Naphthylalyl)-1H-imidazole derivatives, a new class of anticonvulsant agents. J Med Chem 1981, 24, 1, 67.
【3】 Walker, K.A.M. (Syntex (USA), Inc.); 1-(Naphthylethyl)imidazole derivs., their preparation, and pharmaceutical compsns. containing them. EP 0001926 .
【4】 Walker, K.A.M. (Syntex (USA), Inc.); Imidazole derivs., their preparation and their use in pharmaceutical compsns.. EP 0013786 .
【5】 Serradell, M.N.; Blancafort, P.; Castaner, J.; Nafimidone hydrochloride. Drugs Fut 1983, 8, 8, 689.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	36166	2-bromo-1-(2-naphthyl)-1-ethanone	613-54-7	C₁₂H₉BrO	详情	详情
(II)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情

Extended Information