NSC-32122, SOAz, -Drug Synthesis Database

【结构式】

【药物名称】NSC-32122, SOAz

【化学名称】1,3,3,5,5-Pentaziridino-1-thia-2,4,6-triaza-3,5-diphosphorine 1-oxide
　　　　　　1,3,3,5,5-Pentakis(1-aziridinyl)-3,3,5,5-tetrahydro-1H-1,2,4,6,3,5-thiatriazadiphosphorine 1-oxide

【CA登记号】77680-87-6

【分子式】C₁₀H₂₀N₈OP₂S

【分子量】362.3355

【开发单位】Otsuka (Originator), Taiho (Originator)

【药理作用】ONCOLYTIC DRUGS

合成路线1

By reaction of 1,3,3,5,5-pentachloro-1-thia-2,4,6-triaza-3,5-diphosphorine-1-oxide (I) with aziridine (II) in ether.

参考文献中间体

【1】 Van der Huizen, A.A.; Sournies, F.; Labarre, J.F.; Van der Grampel, J.C.; Wiedijk, D.; Jekel, A.P.; Derivatives of cis-NPCl2(NSOCl)2 and (NPCl2)2 NSOCl. Part XVI. The preparation of some aziridino (ethyleneimino) derivatives of (NPCl2)2 NSOX (X=F,Az,Ph) with a potential anticancer activity. Inorg Chim Acta 1981, 53, 4, 169-170.
【2】 Labarre, J.F.; Sournies, F.; Van der Grampel, J.; Van der Huizen, A. (ANVAR (Agence Natl. Valor. Rech.)); Inorganocyclic cpds. usable as medicaments and a process for their preparation. EP 0022407 .
【3】 Blancafort, P.; Castaner, J.; Serradell, M.N.; Hopkins, S.J.; SOAz. Drugs Fut 1983, 8, 7, 605.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	36151	1,3,3,5,5-pentachloro-1lambda(6),2,4,6,3lambda(5),5lambda(5)-thiatriazadiphosphinin-1-one		Cl₅N₃OP₂S	详情	详情
(II)	10151	Ethyleneimine; Aziridine; Azirane	151-56-4	C₂H₅N	详情	详情

Extended Information