Alnovin, Fendosal, P 71-0129, HP-129, -Drug Synthesis Database

【结构式】

【药物名称】Alnovin, Fendosal, P 71-0129, HP-129

【化学名称】5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)salicylic acid
　　　　　　3-(3-Carboxy-4-hydroxy-phenyl)-2-phenyl-4,5-dihydro-3H-benz[e]indole

【CA登记号】53597-27-6

【分子式】C₂₅H₁₉NO₃

【分子量】381.43508

【开发单位】Aventis Pharma (Originator)

【药理作用】Non-Steroidal Antiinflammatory Drugs

合成路线1

The reaction of beta-tetralone (I) with pyrrolidine (A) yields enamine (II), which is condensed with phenacyl bromide (B) in DMF to give the 1-phenacyl-2-tetralone (III). Finally, this diketone is cyclized with 5-aminosalycilic acid (C) in refluxing acetic acid.

参考文献中间体

【1】 Anderson, V.B.; et al.; Carboxyarylindoles as non steroidal anti-inflammatory agents. J Med Chem 1976, 1, 7, 320.
【2】 Castaner, J.; Arrigoni-Martelli, E.; Fendosal. Drugs Fut 1976, 1, 7, 320.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(B)	10315	2-Bromo-1-phenyl-ethanone; 2-Bromo-1-phenyl-1-ethanone	70-11-1	C₈H₇BrO	详情	详情
(A)	11376	Pyrrolidine	123-75-1	C₄H₉N	详情	详情
(I)	39106	3,4-Dihydro-2(1H)-naphthalenone; beta-Tetralone	530-93-8	C₁₀H₁₀O	详情	详情
(II)	20382	1-(3,4-dihydro-2-naphthalenyl)pyrrolidine	21403-95-2	C₁₄H₁₇N	详情	详情
(III)	40460	1-(2-oxo-2-phenylethyl)-3,4-dihydro-2(1H)-naphthalenone		C₁₈H₁₆O₂	详情	详情
(C)	29932	5-amino-2-hydroxybenzoic acid	89-57-6	C₇H₇NO₃	详情	详情

Extended Information