|
【结 构 式】 
|
【药物名称】Pirfenidone, S-7701, AMR-69, Deskar, Pirespa 【化学名称】5-Methyl-1-phenylpyridin-2(1H)-one 【CA登记号】53179-13-8 【 分 子 式 】C12H11NO 【 分 子 量 】185.22757 |
【开发单位】InterMune (Orphan Drug), Marnac (Originator), InterMune (Licensee), Shionogi (Licensee) 【药理作用】Agents for Liver Fibrosis, Diabetic Nephropathy, Agents for, ENDOCRINE DRUGS, GASTROINTESTINAL DRUGS, Immunologic Neuromuscular Disorders, Treatment of, Interstitial Lung Diseases, Treatment of, Liver and Biliary Tract Disorders, Treatment of, Multiple Sclerosis, Agents for, NEUROLOGIC DRUGS, Renal Failure, Agents for, RENAL-UROLOGIC DRUGS, RESPIRATORY DRUGS, Treatment of Diabetic Complications, Treatment of Renal Diseases, TNF-alpha Production Inhibitors |
合成路线1
By condensation of 5-methyl-2-(1H)-pyridone (I) with iodobenzene (II) by means of K2CO3 and Copper powder at reflux temperature.
| 【1】 Gadekar, S.M.; 5-Methyl-1-phenyl-2-(1H)-pyridone compositions and methods of use. CA 1049411; DE 2555411; US 3974281 . |
| 【2】 Gadekar, S.M.; N-Substituted pyridone and general method for preparing pyridones. US 3839346; ZA 7309472 . |
| 【3】 Castaner, J.; Blancafort, P.; Pirfenidone. Drugs Fut 1977, 2, 6, 396. |