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【结 构 式】 
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【药物名称】Disoprofol, Propofol, AM-149(New formulation), ZD-0859, ICI-35868, Ampofol, Propofol IDD-D, Disoprivan, Diprivan 【化学名称】2,6-Bis(1-methylethyl)phenol 【CA登记号】2078-54-8 【 分 子 式 】C12H18O 【 分 子 量 】178.27666 |
【开发单位】AstraZeneca (Originator), Endo (Licensee), RTP Pharma (Licensee), Sicor (Generic), Manhatan Pharmaceuticals (Formulation), NovaDel Pharma (Formulation), SkyePharma (Formulation) 【药理作用】Acute Attacks of Migraine, Treatment of, ANALGESIC AND ANESTHETIC DRUGS, Anesthetic Drugs, Antimigraine Drugs, General Anesthetics, Intravenous Anesthetics, PSYCHOPHARMACOLOGIC DRUGS, Sedative/Hypnotics, Sleep Disorders, Treatment of, Vanilloid VR1 Receptor Agonists |
合成路线1
By condensation of phenol (I) with propylene (II) at temperatures ranging from 230 C to 275 C and pressures up to 3000 atm. in an autoclave, using aluminum phenoxide as catalyst.
| 【1】 Napolitano, J.P.; Ecke, G.G.; Kolka, A.J.; The ortho-alkylation of phenols. J Org Chem 1956, 21, 712-713. |
| 【2】 Kealy, T.J.; Coffman, D.D.; Thermal addition reactions of monocyclic phenols with ethylene. J Org Chem 1961, 26, 987-992. |
| 【3】 Ecke, G.G.; Kolka, A.J.; Napolitano, J.P.; Filbey, A.H.; The ortho-alkylation of phenols. J Org Chem 1957, 22, 642-646. |
| 【4】 Serradell, M.N.; Castaner, J.; Sneddon, J.M.; Blancafort, P.; Disoprofol. Drugs Fut 1982, 7, 3, 156. |