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【结 构 式】 
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【药物名称】Sonolisib 【化学名称】Acetic acid (1E,4S,4aR,5R,6aS,9aR)-1-(diallylaminomethylene)-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,7,10-trioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydrocyclopenta[5,6]naphtho[1,2-c]pyran-5-yl ester 【CA登记号】502844-51-1 【 分 子 式 】C29H35NO8 【 分 子 量 】525.5901 |
【开发单位】Oncothyreon, Inc. (US) 【药理作用】Pan-Phosphatidylinositol 3-Kinase (PI3K) Inhibitor;Oncolytic |
合成路线1
Sonolisib is prepared by condensation of wortmannin (I) with diallylamine (II) in dichloromethane at room temperature .
| 【1】 Powis, G. (University of Arizona). Wortmannin analogs and methods of using same. CA 2458318, EP 1435941, EP 1686124, EP 1914230, JP 2005507880, WO 2003024183. |
Extended Information