| Drug Name |
motexafin gadolinium |
| Description |
Motexafin gadolinium is studied in the treatment of cancer by Pharmacyclics. It may make tumor cells more sensitive to radiation therapy, improve tumor images using magnetic resonance imaging (MRI), and kill cancer cells. It belongs to the family of drugs |
| Structure |
|
| Chemical formula |
C52H72GdN5O14 |
| Average weight |
1148.43167757 |
| Target |
Thioredoxin reductase 1, cytoplasmic;Thioredoxin reductase 2, mitochondrial;Ribonucleoside-diphosphate reductase subunit M2 |
| Indication |
Investigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's). |
| Targets |
Details 1. Thioredoxin reductase 1, cytoplasmic- Kind
- Protein
- Organism
- Human
- Pharmacological action
- unknown
- General Function:
- Thioredoxin-disulfide reductase activity
- Specific Function:
- Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a ...
- Gene Name:
- TXNRD1
- Uniprot ID:
- Q16881
- Molecular Weight:
- 70905.58 Da
Details 2. Thioredoxin reductase 2, mitochondrial- Kind
- Protein
- Organism
- Human
- Pharmacological action
- unknown
- General Function:
- Thioredoxin-disulfide reductase activity
- Specific Function:
- Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
- Gene Name:
- TXNRD2
- Uniprot ID:
- Q9NNW7
- Molecular Weight:
- 56506.275 Da
Details 3. Ribonucleoside-diphosphate reductase subunit M2- Kind
- Protein
- Organism
- Human
- Pharmacological action
- unknown
- General Function:
- Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
- Specific Function:
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
- Gene Name:
- RRM2
- Uniprot ID:
- P31350
- Molecular Weight:
- 44877.25 Da
|
