| Targets |
Details 1. Aldo-keto reductase family 1 member C1- Kind
- Protein
- Organism
- Human
- Pharmacological action
- unknown
- General Function:
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
- Specific Function:
- Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
- Gene Name:
- AKR1C1
- Uniprot ID:
- Q04828
- Molecular Weight:
- 36788.02 Da
References- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Details 2. Aldo-keto reductase family 1 member C2- Kind
- Protein
- Organism
- Human
- Pharmacological action
- unknown
- General Function:
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
- Specific Function:
- Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.
- Gene Name:
- AKR1C2
- Uniprot ID:
- P52895
- Molecular Weight:
- 36734.97 Da
References- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
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