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【结 构 式】 
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【分子编号】67454 【品名】3,3,7-trichloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl pivalate 【CA登记号】 |
【 分 子 式 】C15H16Cl3NO3 【 分 子 量 】364.65508 【元素组成】C 49.41% H 4.42% Cl 29.17% N 3.84% O 13.16% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)
| 【1】 Cordero-Vargas A, Quiclet-Sire B, Zard SZ.2006.A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan. Bioorg Med Chem, 14: 6165～6173. |
| 【2】 Cordero-Vargas A, Perea-Martin I, Quiclet-Sire B, et al.2004.Synthesis of substituted naphthalenes from α-tetralones generated by a xanthate radical addition-cyclisation sequence. Org Biomol Chem, 2: 3018～3025. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 67450 | S-(2-(4-chlorophenyl)-2-oxoethyl) O-ethyl carbonodithioate | C11H11ClO2S2 | 详情 | 详情 | |
| (II) | 67451 | 4-(4-chlorophenyl)-1-((ethoxycarbonothioyl)thio)-4-oxobutyl pivalate | C18H23ClO4S2 | 详情 | 详情 | |
| (III) | 67452 | 7-chloro-4-oxo-1,2,3,4-tetrahydronaphthalen-1-yl pivalate | C15H17ClO3 | 详情 | 详情 | |
| (IV) | 67453 | (E)-7-chloro-4-(hydroxyimino)-1,2,3,4-tetrahydronaphthalen-1-yl pivalate | C15H18ClNO3 | 详情 | 详情 | |
| (V) | 67454 | 3,3,7-trichloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl pivalate | C15H16Cl3NO3 | 详情 | 详情 | |
| (VI) | 67455 | 7-chloro-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl pivalate | C15H18ClNO3 | 详情 | 详情 | |
| (VII) | 67456 | 7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl pivalate | C15H20ClNO2 | 详情 | 详情 | |
| (VIII) | 67457 | 7-chloro-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl pivalate | C23H25ClN2O5 | 详情 | 详情 | |
| (IX) | 67458 | 1-(4-amino-2-methylbenzoyl)-7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl pivalate | C23H27ClN2O3 | 详情 | 详情 | |
| (X) | 67459 | 7-chloro-1-(2-methyl-4-(2-methylbenzamido)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl pivalate | C31H33ClN2O4 | 详情 | 详情 |
Extended Information