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【结 构 式】 
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【分子编号】66989 【品名】11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,5-a]azepine 【CA登记号】 |
【 分 子 式 】C17H19N3 【 分 子 量 】265.35808 【元素组成】C 76.95% H 7.22% N 15.84% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)
| 【1】 da Silva RA, Estevam IHS, Bieber LW. 2007. Reductive methylation of primary and secondary amines and amino acids by aqueous formaldehyde and zine. Tetrahedron Lett. 48(43): 7680～7682 |
| 【2】 Patel CH, Dhannani S, Owen CP, et al. 2006. Synthesis, biochemical evaluation and rationalization of theinhibitory activity of a range of 4-substituted phenyl alkyl imidazolebases inhibitors of the enzyme complex 17-hydroxylase/17,20-lyase(P45017). Bioorganic & Medicinal Chemistry Letters, 16(18): 4752～4756 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
| (II) | 66985 | 1H-Imidazole,1-(2-phenylethyl)-;1-Phenethylimidazole | 49823-14-5 | C11H12N2 | 详情 | 详情 |
| (III) | 66986 | ethyl 4-(1-phenethyl-1H-imidazole-5-carbonyl)piperidine-1-carboxylate | C20H25N3O3 | 详情 | 详情 | |
| (IV) | 66987 | (1-phenethyl-1H-imidazol-5-yl)(piperidin-4-yl)methanone | C17H21N3O | 详情 | 详情 | |
| (V) | 66988 | (1-methylpiperidin-4-yl)(1-phenethyl-1H-imidazol-5-yl)methanone | C18H23N3O | 详情 | 详情 | |
| (VI) | 66989 | 11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,5-a]azepine | C17H19N3 | 详情 | 详情 | |
| (VII) | 66990 | (11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,5-a]azepin-3-yl)methanol | C19H23N3O | 详情 | 详情 |
Extended Information