(4aR,6S,8aR)-6-hydroxy-3-methoxy-11-methyl-5,6,11,12-tetrahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-10(9H)-one -Drug Synthesis Database

【结构式】

【分子编号】66428

【品名】(4aR,6S,8aR)-6-hydroxy-3-methoxy-11-methyl-5,6,11,12-tetrahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-10(9H)-one

【CA登记号】　

【分子式】C₁₇H₁₉NO₄

【分子量】301.3422

【元素组成】C 67.76% H 6.36% N 4.65% O 21.24%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVII)

参考文献中间体

合成目标

【1】 Hu XD, Tu YQ, Zhang E,et aL 2006.Total synthesis of (±)-galanthamine. Org Lett,8(9): 1823--1825

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XI)	66422	(4aR,9bR)-9b-((1,3-dioxolan-2-yl)methyl)-6-methoxy-4,4a-dihydrodibenzo[b,d]furan-3(9bH)-one		C₁₇H₁₈O₅	详情	详情
(I)	11377	1,4-Dioxaspiro[4.5]decan-8-one	4746-97-8	C₈H₁₂O₃	详情	详情
(II)	66414	2,4,6-triisopropylbenzenesulfonohydrazide	39085-59-1	C₁₅H₂₆N₂O₂S	详情	详情
(III)	66415	2,4,6-triisopropyl-N'-(1,4-dioxaspiro[4.5]decan-8-ylidene)benzenesulfonohydrazide		C₂₃H₃₆N₂O₄S	详情	详情
(IV)	56675	2-{[tert-butyl(dimethyl)silyl]oxy}-3-methoxybenzaldehyde		C₁₄H₂₂O₃Si	详情	详情
(V)	66416	(2-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)(1,4-dioxaspiro[4.5]decan-8-yl)methanol		C₂₂H₃₆O₅Si	详情	详情
(VI)	66417	(7S,8R)-7-bromo-8-(2-((tert- butyldimethylsilyl)oxy)-3-methoxyphenyl)- 1,4-dioxaspiro[4.5]decane-8-carbaldehyde		C₂₂H₃₃BrO₅Si	详情	详情
(VII)	66418	(4aR,9bS)-6-methoxy-2,4,4a,9b-tetrahydro- 1H-spiro[dibenzo[b,d]furan-3,2'-[1,3] dioxolane]-9b-carbaldehyde		C₁₆H₁₈O₅	详情	详情
(VIII)	66419	(4aR,9bS)-6-methoxy-9b-((E)-2- methoxyvinyl)-2,4,4a,9b-tetrahydro-1H-spiro [dibenzo[b,d]furan-3,2'-[1,3]dioxolane]		C₁₈H₂₂O₅	详情	详情
(IX)	66420	(4aR,9bS)-9b-((1,3-dioxolan-2-yl)methyl)-6-methoxy-1,4,4a,9b-tetrahydrodibenzo[b,d]furan-3(2H)-one		C₁₇H₂₀O₅	详情	详情
(X)	66421	(((4aR,9bS)-9b-((1,3-dioxolan-2-yl)methyl)-6-methoxy-1,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl)oxy)trimethylsilane		C₂₀H₂₈O₅Si	详情	详情
(XII)	66423	(3S,4aR,9bR)-9b-((1,3-dioxolan-2-yl)methyl)-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-ol		C₁₇H₂₀O₅	详情	详情
(XIII)	66424	(5aR,7S,9aS)-7-hydroxy-4-methoxy-5a,6,7,9a-tetrahydrodibenzo[b,d]furan-9a-carbaldehyde		C₁₄H₁₄O₄	详情	详情
(XIV)	66425	(3S,4aR,9bS)-9b-formyl-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl acetate		C₁₆H₁₆O₅	详情	详情
(XV)	66426	(3S,4aR,9bR)-9b-(2-bromo-2-oxoethyl)-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl acetate		C₁₇H₁₇BrO₅	详情	详情
(XVI)	66427	(3S,4aR,9bR)-6-methoxy-9b-(2-(methylamino)-2-oxoethyl)-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl acetate		C₁₈H₂₁NO₅	详情	详情
(XVII)	66428	(4aR,6S,8aR)-6-hydroxy-3-methoxy-11-methyl-5,6,11,12-tetrahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-10(9H)-one		C₁₇H₁₉NO₄	详情	详情

Extended Information