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【结 构 式】 
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【分子编号】65332 【品名】2-methylindole-3-glyoxylamide 【CA登记号】 |
【 分 子 式 】C10H10N2O2 【 分 子 量 】190.20168 【元素组成】C 63.15% H 5.3% N 14.73% O 16.82% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Reduction of 2-methylindole-3-glyoxylamide (I) with LiAlH4 affords 2-methyltryptamine (II). 4-Formylcinnamic acid (III) is esterified with methanolic HCl, and the resulting aldehyde ester (IV) is reductively aminated with 2-methyltryptamine (II) in the presence of NaBH3CN to give (V). The title hydroxamic acid is then obtained by treatment of ester (V) with aqueous hydroxylamine under basic conditions (1). Scheme 1.
| 【1】 Bair, K.W., Green, M.A., Perez, L.B., Sharma, S.K., Sambucetti, L., Versace, R.W., Remiszewski, S.W. (Novartis AG; Novartis Pharma GmbH). Deacetylase inhibitors. EP 1318980, JP 2004509105, WO 0222577. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 65332 | 2-methylindole-3-glyoxylamide | C10H10N2O2 | 详情 | 详情 | |
| (II) | 65333 | 2-Methylindole-3-ethylamine; 2-(2-Methyl-1H-indol-3-yl)-ethylamine; 3-(2-Aminoethyl)-2-methylindole | 2731-06-8 | C11H14N2 | 详情 | 详情 |
| (III) | 55571 | 4-Formylcinnamic acid | 23359-08-2 | C10H8O3 | 详情 | 详情 |
| (IV) | 46515 | methyl (E)-3-(4-formylphenyl)-2-propenoate | 7560-50-1 | C11H10O3 | 详情 | 详情 |
| (V) | 65334 | C22H23N2O2 | 详情 | 详情 |
Extended Information